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Published:
Oct 11, 2023DOI:
10.4314/ahs.v23i3.65Keywords:
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Main Article Content
Effects of interventional vascular embolization at different timing on prognosis and serum S100 calcium-binding protein B level of patients with aneurysmal subarachnoid hemorrhage
Abstract
Objective: To evaluate the effects of interventional vascular embolization at different timing on the prognosis and serum S100
calcium-binding protein B (S100B) level of patients with aneurysmal subarachnoid hemorrhage (aSAH).
Methods: A total of 229 aSAH patients enrolled from January 2016 to January 2020 were divided into an early-stage group
(n=66), a middle-stage group (n=95) and a late-stage group (n=68. Their baseline data, serum indices and clinical outcomes were
compared. The factors affecting their prognosis were analysed. The value of serum S100B level for predicting the prognosis was
evaluated.
Results: The early-stage group had the highest GOS score, and the late-stage group had the lowest score (P<0.05). Older age,
large diameter of aneurysm, high Hunt-Hess grade upon admission, late surgical treatment and high S100B level were risk factors
for the poor prognosis of aSAH patients. The optimal cut-off value of S100B for predicting the prognosis was 2.785 μg/L.
The area under the receiver operator characteristic curve, sensitivity, specificity, Youden index and 95% confidence interval were
0.892, 84.3%, 86.3%, 0.706 and 0.844-0.940, respectively.
Conclusion: Early vascular interventional embolization is beneficial to the alleviation of brain injury and the reduction of serum
S100B level.
Keywords: Aneurysmal subarachnoid hemorrhage; interventional vascular embolization; prognosis; S100 calcium-binding protein
B; timing.
