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Aspergillus-specific IgM/IgG antibody serostatus of patients hospitalized with moderate-critical COVID-19 in Uganda


Felix Bongomin
Richard Kwizera
Emmanuel Mande
Sharley Melissa Aloyo
Beatrice Achan
Martha Namusobya
Senai Goitom Sereke
Charles Batte
Sarah Kiguli
Joseph Baruch Baluku
Moses L Joloba
Bruce J Kirenga

Abstract

Invasive pulmonary aspergillosis is known to complicate the coronavirus diseases-2019 (COVID-19), especially those with critical
illness. We investigated the baseline anti-Aspergillus antibody serostatus of patients with moderate-critical COVID-19 hospitalized
at 3 COVID-19 Treatment Units in Uganda. All 46 tested patients, mean age 30, and 11% with underlying respiratory
disease had a negative serum anti-Aspergillus IgM/IgG antibody immunochromatographic test on day 3 (mean) of symptom
onset (range 1-26), but follow up specimens to assess seroconversion were not available.


Keywords: Invasive pulmonary aspergillosis; COVID-19; critical illness; Uganda.


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eISSN: 1729-0503
print ISSN: 1680-6905