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Published:
Apr 29, 2022DOI:
10.4314/ahs.v22i1.78Keywords:
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Main Article Content
Vitamin A- and C-rich Pouteria camito fru it derived superparamagnetic nanoparticles Synthesis, characterization, and their cytotoxicity
Abstract
Background: Recently, green nanoparticles are gaining importance in drug development because of their lower toxicity, sustainability, cost effectiveness, simplicity, and ecofriendly nature compared with toxic chemicals.
Objective: In this study, we developed a nontoxic method for synthesizing iron oxide nanoparticles by using the fruit of Pouteria caimito that is rich in vitamin A and C and evaluated their cytotoxicity.
Methods: Pouteria caimito fruit¬–derived superparamagnetic nanoparticles (PCSNs) were characterized using physical and chemical methods, and their cytotoxicity was examined using the 3-(4, 5-dimethylthiazol-2-yl)-2–5-diphenyltetrazolium bromide (MTT) assay.
Results: Ultraviolet–visible spectroscopy (UV–Vis spectro) analysis of PSNs showed a peak at 277 nm. Transmission electron microscopy (TEM) findings showed that PSNs exhibited a nanorod shape with their sizes ranging from 9.41 nm to 16.96 nm (average size: 13.08 nm). The findings of dynamic light scattering (DLS) indicated that the particle size was 186.
6–847.3 d.nm with an average of 367.5 d.nm. The Zeta potential analysis indicated that PSNs exhibited uniform surface charge distribution, and their surface charge was equal to −13.7 mV. Fourier-transform infrared spectroscopy (FTIR) analysis showed background-color:#fcfcfc">that PSNs exhibited bands at 3412, 1629, 1384, 1075, 818, 697, and 471 cm−1.
Energy-dispersive X-ray spectroscopy (EDX) results showed that iron was the major element present in PCSNs, followed by other biomolecules such as C, O, and Cl, indicating the production of iron oxide nanoparticles.
Conclusion: The Pouteria caimito fruit that possesses strong oxidizing and nontoxic properties can be a potentially attractive source for the production of iron oxide nanoparticles. Moreover, the cytotoxicity assay results revealed that iron oxide nanoparticles synthesized using the Pouteria caimito fruit extract derived can be used for targeting cancer cells and treating other diseases because of their nontoxic nature. These nanoparticles can be used for the treatment of cancer and other diseases in the future.
Keywords: Fruit; Pouteria caimito; ferric chloride; superparamagnetic nanoparticles; cytotoxicity.
