Renal Dysfunction and Hyperlipidaemia in Hypertensive and Diabetic Patients

Abstract

Hyperlipidaemia and renal dysfunction in four groups of patients( hypertensive diabetics, hypertensive , diabetic patients and normal individuals)was assessed using biochemical markers such as Urea, Creatinine , Cholesterol, Triglyceride, HDL-C, LDL-C and Fasting blood sugar(FBS) . A total of 84 adults’ subjects aged between 20 and 65 years consisting of 22hypertensive, 22 hypertensive diabetics, 20 diabetics and 20 apparently healthy individuals (which served as control) were used for the study all within Aba Metropolitan.The investigations were done with serum and the biochemical parameters were assayed based on calorimetric method. However, the results obtained were subjected to statistical analysis. From the results, it was observed that there was a significant increase in the serum levels of Urea and Creatinine in hypertensive diabetics compared to hypertensive, diabetics and control subjects (P<0.05).Although, there was a slight increase in the levels of Triglyceride and LDL-C in the same group compared to others. Equally indicated was that diabetics exhibited slight increase in Fasting blood sugar (FBS) compared to the other three groups (control Mmol/L; 4.32±0.60 vs 7.34±0.92 vs 4.90± 0.50 vs 10.80± 1.05, P<0.05). The study has established a renal dysfunction in hypertensives and diabetics. Equally noted was hyperlipidaemia in the groups studied. The study is therefore stressing the importance of controlling hyperlipidaemia in Hypertensive diabetics, Hypertensive and Diabetic patients, since it is a major risk factor for atherosclerosis and cardiovascular diseases.

Key words:Renal Dysfunction, Hyerlipidaemia, Hypertensives, Diabetics.