Abrogation by human menopausal gonadotropin on testicular disorders induced by cisplatin in adult male rats

Abstract

Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of cancer cells including testicular cancer. Human Menopausal Gonadotropin (HMG) is a natural hormone necessary for human reproduction. This hormone is a leading modality of treatment for infertility as it contains equal amount of Follicle Stimulating Hormone (FSH) and
Luteinizing Hormone (LH). The present study investigated the possible counter effect of HMG on testicular disorders induced by Cisplatin administration in adult male rats. 20 adult male rats were equally divided into four groups; A, B, C and D which were the control, Cisplatin (2.5mg/kg), HMG (3.1 IU/kg) and Cisplatin (2.5mg/kg)+HMG (3.1 IU/kg)groups respectively. The animals were sacrificed after 56 days. Decrease in total sperm count, sperm motility and increase in abnormal sperm were observed in the group treated with Cisplatin. These negative effects were seen to be abrogated in animals in group D treated with Cisplatin and HMG.

KEY WORDS: Cisplatin, Human Menopausal Gonadotropin, sperm count, sperm motility,
sperm morphology