Effect of aqueous extract of Allium sativum on liver function profile in wistar rat

Abstract

Hepatic dysfunction is globally a major health catastrophe that challenges the health care of many people worldwide.The existing synthetic drugs to treat liver diseases have appeared not to give much satisfactory outcomes. Therefore, the aim of this study is to evaluate the effects of Allium sativum extracts on liver function. The animals were divided into four groups. Group A serves as control and were given distilled water daily for a period of five weeks. Groups A,B and C were given aqueous extract of Allium sativum orally at doses of 150, 300 and 600mg/kg body weight respectively . Administration of Allium sativum extract at doses of 150, 300 and 600 mg/kg bwt for period of five weeks led to significant (p˂0.05) decreases in the serum activities of Liver marker enzymes and some biochemical parameters as compared to the control group. There were significant (p˂0.05) increases in the serum level of total protein (TP), and albumin (ALB), especially at dose of 150 mg/kg bwt as compared to control group. The result also revealed significant (p˂0.05) decrease in the liver tissue level of malondialdehyde (MDA), and significant (p˂0.05) increases in the activities of antioxidant enzymes, superoxide dismutase,SOD, glutathione peroxidaseGPx. and catalase, CAT in the Liver tissues.  Therefore, the results from this study supported the evidence of non toxic effect of Allium sativum at the doses tested .

Keywords: Allium Sativum, Liver function profile