Anti-ulcer activity of Brassica oleracea on induced gastrointestinaltract injury in albino wistar rats

Abstract

Brassica oleracea has been used historically as a medicinal herb for a variety of health conditions. This study was conducted to determine the efficacy of Brassica oleracea in healing induced upper gastrointestinal tract injury in Albino Wistar rats. Brassica oleracea was procured from vegetable market and authenticated. A total of 20 Albino Wistar rats of both sexes weighing between 120g-150g were used and were randomly shared into five groups which include- two control groups and three treated groups. The animals were sacrificed following mild anesthesia using chloroform inhalation. The dissected stomach and duodenum were examined macroscopically, tissue blocks taken, fixed in 10% formol saline and prepared for histopathological diagnosis. Brassica oleracea exhibited better healing activity of gastric ulcers than the duodenal ulcers and higher concentrations at 300mg/kg did not produce better results. Further studies to elucidate the efficacy and the appropriate dosage of Brassica oleracea in the treatment of peptic ulcer are advoca.