Lipid Peroxidation and lipid Profile in Hypertensive Patients in Sokoto, Nigeria

Abstract

Hypertension and dyslipidaemia are associated with oxidative stress and are major causes of cardiovascular disease amounting to 30% of global death rate. In the current work, malondialdehyde and lipid profile were estimated in sixty hypertensive patients attending outpatient clinic of the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the results compared with those of apparently healthy non-hypertensive volunteers of comparable age and social status. Serum levels of MDA, TC, TG, LDL-C, VLDL-C and AIX in hypertensive subjects were 122.80±14.66, 6.99 ± 0.59, 2.49 ± 0.23, 3.68 ± 0.63, 1.14 ± 0.23 and 2.02 ± 0.65 mmol/l respectively while in non hypertensive subjects the results were 60.14 ± 11.20, 5.31 ± 0.89, 1.79 ± 0.65, 0.71 ± 0.52, 0.83 ± 0.32 and 0.21 ± 0.19 mmol/l respectively. There were significantly (P< 0.05) higher levels in hypertensives. The serum HDL-C was significantly (p<0.05) lower in hypertensives (2.29 ± 0.41 mmol/l) than in non-hypertensives ( 3.89 ±
0.76 mmol/l ) subjects respectively. There were higher incidences (71%) of lipid peroxidation and dyslipidaemia in the hypertensives. The results suggest that hypertensives in the study area have high serum levels of MDA and lipid profile, an indication that the hypertensives are predisposed to increased oxidative onslaught.
Keywords: Hypertensive, malondialdehyde, dyslipidaemia, lipid profile.