Synthesis and crystal structure of 1-[2-(3-ethyl-2,2-dimethylcyclobutyl)acetyl]-3-phenyl thiourea

Abstract

The title compound 1-[2-(3-ethyl-2,2-dimethylcyclobutyl)acetyl]-3-phenylthiourea has been synthesized and its crystal structure was studied. The crystal belongs to triclinic system, space group P-1, a = 10.200(2) Ǻ, b = 12.395(3) Å, c = 15.679(3) Å, α = 92.99(2)^o, β = 106.00(3)^o, γ = 111.95(3)^o, V = 1740.4(6) ų, Z = 2, μ = 0.187 mm⁻¹, D_c = 1.162 g/cm³, F(000) = 656, R = 0.0784, wR2 = 0.1505, formula unit C₁₇H₂₄N₂OS. The title compound has a fragment of 2,2-dimethylcyclobutane and its conformation represents semi-chair. The intermolecular and intramolecular hydrogen bonds are revealed.

KEY WORDS: Synthesis, Single crystal X-ray diffraction, Crystal structure, 2,2-Dimethylcyclobutane

Bull. Chem. Soc. Ethiop. 2013, 27(1), 125-129.

DOI: http://dx.doi.org/10.4314/bcse.v27i1.13