Main Article Content
<b>Synthesis of substituted flavone derivatives as potent antimicrobial agents</b>
Abstract
The biological activity of flavone has been enhanced by introducing heteroaryl moiety in C-2 position of chromone derivatives. Thus, 2-(1H-Indol-3-yl)-4H-chromen-4-one derivatives (6a-e) and 2-(2-chloroquinolin-3-yl)-4H-chromen-4-one derivatives (7a-e) were synthesized from corresponding chalcone. They were structurally confirmed by analytical and spectral data and evaluated for their antimicrobial activities. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents.
KEY WORDS: Chalcone, Flavone, Chromone, Antibacterial activity, Antifungal activity
Bull. Chem. Soc. Ethiop. 2011, 25(3), 419-425.