Bulletin of the Chemical Society of Ethiopia
Journal / Bulletin of the Chemical Society of Ethiopia / Vol. 19 No. 2 (2005) / Articles
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Published:
Nov 22, 2005
DOI:
10.4314/bcse.v19i2.21127
Keywords:
<i>Erythrophleum suaveolens</i> (Guill. & Perr.) Brenan Norcassaide Diterpenoid alkaloid Norerythrosuaveolide Antimicrobial activities Bacteria Yeasts

Article Details

Issue
Vol. 19 No. 2 (2005)
Section
Articles

Main Article Content

ANTIMICROBIAL DITERPENOID ALKALOIDS FROM ERYTHROPHLEUM SUAVEOLENS (GUILL. & PERR.) BRENAN


F.N. Ngounou
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
R.N. Manfouo
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
L.A. Tapondjou
Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 183, Dschang, Cameroon
D. Lontsi*
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
V. Kuete
Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
V. Penlap
Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
F.X. Etoa
Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
M-A.L. Dubois
Laboratoire de Pharmacognosie, Unité des Molécules d’Intérêt Biologique, UMIB EA3660, Faculté de Pharmacie, Université de Bourgogne, 7, Bd Jeanne d'Arc, 21079, Dijon Cedex, France
B.L. Sondengam
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon

Abstract

An investigation of the stem bark of Erythrophleum suaveolens (Guill. & Perr.) Brenan yielded the known amide norcassaide (1) and a new diterpenoid alkaloid named norerythrosuaveolide (2) which was characterized as 7β-hydroxy-7-deoxo-6-oxonorcassaide. The structures were established on the basis of one and two-dimensional 1H and 13C NMR spectral data. The compounds showed potent antimicrobial activities against bacteria and yeasts.



KEY WORDS: Erythrophleum suaveolens (Guill. & Perr.) Brenan, Norcassaide, Diterpenoid alkaloid, Norerythrosuaveolide, Antimicrobial activities, Bacteria, Yeasts


Bull. Chem. Soc. Ethiop. 2005, 19(2), 221-226.

Journal Identifiers


eISSN: 1726-801X
print ISSN: 1011-3924
 
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