Synthesis and in vitro antimicrobial evaluation of 5-amino-7-aryl-6-cyano-4H- pyrano[3,2,b]pyrrole derivatives catalyzed by reusable ZrOCl2•8H2O

Abstract

An efficient synthesis of a new series of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole derivatives from the reaction of 3-hydroxypyrrole, malononitrile, and various aromatic aldehydes using ZrOCl₂·8H₂O, an environmentally friendly catalyst under a thermal solvent-free green procedure is described. This simple protocol offer advantages such as shorter reaction times, simple work-up and excellent yield. The catalyst ZrOCl₂·8H₂O can be reused. The reusability of the catalyst has been studied for the synthesis of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole. All the compounds were screened for their antibacterial and antifungal activity.

KEY WORDS: ZrOCl₂·8H₂O, Pyranopyrrole, Malononitrile, 3-Hydroxypyrrole, Solvent-free

Bull. Chem. Soc. Ethiop. 2014, 28(1), 91-100.

DOI:http://dx.doi.org/10.4314/bcse.v28i1.11

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