The effect of Selenium supplementation on the chemotherapeutic efficacy of diminazene aceturate (Berenil®) and isometamidium chloride (Samorin®) was studied. Thirty-six adult albino rats were randomly assigned into 6 Groups (A – F) of 6 rats each and were treated as follows; Group A= Samorin® only, Group B = Samorin® + Selenium, Group C
= Berenil® only, Group D = Berenil® + Selenium and Group E = infected untreated control whereas Group F served as uninfected untreated control. The supplementation prolonged relapse interval in Samorin® + Selenium treated group and prevented relapse in Berenil® + Selenium group. Supplementation also appeared to have improved the blood values of the treated rats with the PCV and RBC count of the infected untreated
group being significantly (p